Corinne Nardin: Biologically active polymer structures

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Corinne NardinBiologically active polymer structures

Corinne Nardin was named full professor of physics at the Université de Pau et des Pays de l’Adour (UPPA) in 2015. She became part of the polymer physics and chemistry team (EPCP) of the IPREM to strengthen the team's work in biomimetism and biophysics.

Over the course of her career, Corinne Nardin's work has focused on the design of biologically active polymer structures of potential for biological and medical uses. For this, she was awarded a professorship from the Swiss National Science Foundation for Research (SNSF) in 2011, for 6 years, hosted by the Department of Inorganic and Analytical Chemistry (Chemistry and Biochemistry School, University of Geneva, Switzerland).

Trained as a physicist, she became acquainted with polymer chemistry when she began to tackle issues related to the synthesis of biohybrid polymers and the design of inorganic/organic hybrids thereof. The structures resulting from their structuration are of potential for applications in drug delivery or gene therapy. In a biomimetic approach, biohybrid polymers are also model systems useful for establishing the mechanism of structure formation of some proteins, namely amyloids, which have been identified in several types of pathologies, in particular neurodegenerative diseases.

To counterbalance their pathogenic association, Corinne Nardin adopted a biophysics approach, adapting the theories and methods mastered in polymer and colloid science to establish a comprehensive understanding of the pathogenic structuration of these proteins and of the structures resulting from their interaction with polymer of biological relevance. To this end, she recently demonstrated that upon interaction with single stranded DNA sequences, the association of the amyloid protein involved in Alzheimer’s disease is affected according to the formation of a complex well known in polymer science, where oppositely charged amino and nucleic acid biopolymers form an interpolyelectrolyte complex by electrostatic interaction. Similar biomimetic and biophysics approaches are currently adopted to tackle issues related to bacterial adhesion and cell targeting for sustained drug or gene delivery.

Her research outputs are as follows (source web of science): H index of 16 (40 publications); 4 book chapters and 3 patents; citation number: 1479.